A comparative study of the catalytic activity of nanosized oxides in the one-pot synthesis of highly substituted dihydropyridines

چکیده مقاله

A four-component reaction of aromatic aldehydes, ethyl cyanoacetate, arylamines, and dimethyl acetylenedicarboxylate has been achieved in the presence of nanosized oxides (ZnO NPs, CuO NPs, CeO2 NPs, SnO NPs, MgO NPs and CaO NPs) as highly effective heterogeneous catalysts to produce polysubstituted dihydropyridines. Extraordinarily, the best results were obtained using CeO2 nanoparticles as an efficient catalyst. This method provides several advantages, including mild reaction conditions, applicability to a wide range of substrates, reusability of the catalyst and minimal catalyst loading.