one-pot synthesis of spiro-furo-pyrido-pyrimidine-indoline derivatives by using a highly active magnetically reusable nanocatalyst in green media

چکیده مقاله

Multicomponent reactions (MCRs) are special types of synthetically useful organic reactions in which three or more different starting materials come together in a single reaction vessel to give a final product containing substantial elements of all the reactants [1]. The use of water as a green solvent for organic synthesis has recently attracted considerable attention. Organic reactions carried out in water, without the use of any hazardous and flammable organic solvents are one of the current focuses today especially in our environmentally conscious society [2]. Magnetic nanoparticles have gained considerable interest in various disciplines such as ferrofluids, drug delivery, magnetic resonance imaging (MRI), cancer hyperthermia treatment, biomolecular sensors, bioseparation, and have emerged as a useful group of heterogeneous catalysts because of their extremely small size and large surface to volume ratio and they can be separated from the reaction medium after magnetization by an external magnet [3]. Spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid and natural products, with interesting structural properties and wide range of useful pharmacological properties and biological activities, such as antimicrobial, antitumoral, antibiotic agents, inhibitors of human NK-1 receptor, and inhibitors of microtubule assembly [4,5]. we report herein a facile, efficient, eco-friendly and one-pot process for the synthesis of novel spiro-furo-pyrido-pyrimidine-indoline derivatives in the presence of manganese ferrite nanoparticles as an efficient and reusable catalyst in water.