A rapid and high efficient microwave promoted multicomponent domino reaction for the synthesis of spirooxindole derivatives

چکیده مقاله

The development of efficient formation of multifunctionalized complex products such as natural products and analogs, drugs, diagnostics and etc. by using simple reactants has been an important issue in organic synthesis [I]. In this regard, multi-component domino reactions have become increasingly attractive and the best tools in modern organic synthesis and medicinal chemistry, because of their green characteristics of atom-economy, bond-forming economy, and structural economy [2). The use of microwaves as a valuable and powerful technology has become a major motivation for both industry and academia. Replacing the oil bath with a microwave reactor, opens a new window to perform reactions in dramatically shortened time as well as increasing yields and the involved reactions are often very cleaner [3). Ox indole derivatives for decades have drown great attention because these compounds are characterized by extensive applications in biology and pharmacology as well as the presence of this framework in a number of natural products [4, 5).