Ultrasound effect for an efficient three-component synthesis of ۱H spiro[furo[۳,۴- bJpyridine-۴,۳' -indolineJ-۳-carbonitrile

چکیده مقاله

Multicomponent reactions (MCRs), in which multiple starting materials react together via a one-pot procedure to form a final product without isolating the intermediates, are special types of synthetically important organic reactions in combinatorial and medicinal chemistry [1-2). Recently, the application of ultrasound as a powerful technique in synthetic organic chemistry became extremely efficient and attractive. The prominent features of the ultrasound approach are enhanced organic reaction rates, formation of purer products in high yields, mild reaction conditions, and considered a processing aid in terms of energy conservation and waste minimization compared with traditional methods [3). Spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid and natural products, with interesting structural properties and wide range of useful pharmacological properties and biological activities, such as antimicrobial, antitumoral, antibiotic agents, inhibitors of human NK- 1 receptor, and inhibitors of microtubule assembly [4-5).