Studing the interaction of some anthraquinone derivatives with DNA in comparison with doxorubicin

چکیده مقاله

Anthraquinones are an important group of organic compound that most of these substances came from plants and fungi. Anthraquinone compounds are structurally similar to anthracycline antibiotics such as doxorubicin. Doxorubicin is an anticancer drug that commonly used in the treatment of a wide range of cancers including hematological malignancies, many types of carcinoma and soft tissue sarcomas [1]. It interacts with DNA by intercalation and inhibition of DNA replication [2]. As DNA is often the target for majority of antitumor and antibiotic drugs, therefore, investigation of the mechanism of action and identification of drug interaction with DNA in cells at the molecular level to develop potent drugs and exploration is an essential requirement [3]. It seems that anthraquinone compounds with structural similarity to doxorubicin can have interaction with DNA. So in the present study two anthraquinone derivatives such as 1,4-dimethylanthraquinone and 2-methylanthraquinone were analyzed for its possible interaction with chicken liver DNA in Tris-HCl buffer (pH=7.4) by UV-Vis spectroscopy and their interaction was compared with Doxorubicin. The results shown that doxorubicin has more effective interaction with DNA than anthraquinone compounds. Spectroscopy studies showed that interaction of anthraquinone compounds with DNA as doxorubicin is dose dependent and the interaction of 1,4-dimethylanthraquinone with DNA is more than 2-methylanthraquinone .