Synthesis of β-hydroxy-1,2,3-triazoles catalyzed by graphene oxide@polytriazole-Cu via multicomponent reaction in aqueous media

چکیده مقاله

A solid-supported catalyst for Huisgen’s [3+2] cycloaddition reaction between azides and alkynes was prepared from copper (I) iodide and 1,2,3-triazole functionalized graphene oxide (GO). This catalyst was then used for efficient synthesis of β-hydroxy-1,2,3-triazoles giving access to these products in excellent yields. In this protocol, the catalyst was shown high activity, air-stable, stability, and recycling capabilities. The formation of copper triazolide is very straightforward and energetically desirable. GO@polytriazole-Cu (GO@PTA-Cu) can be isolated from copper-catalyzed azide–alkyne cycloaddition (CuAAC) reactions.