| نویسندگان | مهنوش حق شناس,محمد مظلوم اردکانی,زهرا علیزاده,فرشته وجه الدین,حسین نعیمی |
|---|
| نشریه | ELECTROANAL |
|---|
| شماره صفحات | 1 |
|---|
| شماره مجلد | 32 |
|---|
| ضریب تاثیر (IF) | ثبت نشده |
|---|
| نوع مقاله | Full Paper |
|---|
| تاریخ انتشار | 2020-06-30 |
|---|
| رتبه نشریه | علمی - پژوهشی |
|---|
| نوع نشریه | الکترونیکی |
|---|
| کشور محل چاپ | ایران |
|---|
| نمایه نشریه | JCR |
|---|
چکیده مقاله
Developing anticancer sensing platforms has a
significant impact on individual cancer treatment. Monitoring
of anticancer drugs in bodily fluid allows doctors
to prescript the efficient amount of drugs that significantly
lower chemotherapy side effects on individuals. In this
study, for the first time, we explored a chemically
modified carbon paste electrode (CPE), containing 2, 2’-
(1, 6-hexanediylbisnitrilo-ethylidine)-bis-hydroquinone
(HEH) and Ag@Pt/multiwalled carbon nanotubes
(MWCNTs), to monitor hydroxyurea (HU), a highly toxic
anticancer drug, in human serum. The electrochemical
study was carried out to determine the electrocatalytic
rate constant, the diffusion coefficient, and the electrontransfer
coefficient of HU oxidation. The DPV of HU
showed three linear dynamic ranges in the concentration
ranges of 0.05 to 1.0 μM, 1.0 to 50.0, and 50.0 to
1000.0 μM. The detection limit was lowered to 23.0 nM.
With this sensing platform, DPV peaks of mixed HU and
uric acid (UA) could be isolated from each other,
indicating satisfied selectivity. The proposed electrochemical
sensor serves as a handy device for monitoring of HU
in clinical samples.
