|نویسندگان||وجیهه نژادشفیعی دخت,حسین نعیمی|
|نشریه||CURR ORG SYNTH|
|ضریب تاثیر (IF)||1.841|
|نوع مقاله||Full Paper|
|رتبه نشریه||علمی - پژوهشی|
|کشور محل چاپ||ایران|
چکیده مقالهA novel and convenient transformation for the synthesis of benzodiazepines has been developed via catalytic cyclization reaction using ionic liquid supported on mesoporous silica nanoparticles- imprinted iron metal (Fe-MCM-41-IL) as a recyclable catalyst under mild conditions. Materials and Methods: For preparation of Fe-MCM-41-IL, FeCl3·6H2O was added to a mixture of distilled water, CTAB and NaOH aqueous solution. The tetraethyl orthosilicate was dropped into the solution under stirring. The product was separated, washed, and dried. The solid product was collected and calcined. Then, to a solution of β-hydroxy-1,2,3-triazole in toluene, 3-chloropropyltrimethoxysilane was added and the mixture was refluxed. The Conc. H2SO4 was added dropwise into the above solution and stirred. For immobilization of IL onto Fe-MCM-41, the solution IL was added to Fe-MCM-41 and was refluxed for the production of the Fe- MCM-41. Following this, benzodiazepines were synthesized using Fe-MCM-41-IL as a catalyst.
tags: Ionic liquid, mesoporous, Fe-MCM-41-IL, nanocatalyst, benzodiazepines, synthesis