Facile three-component preparation of benzodiazepine derivatives catalyzed by zinc sulfide nanoparticles via grinding method

نویسندگانحسین نعیمی,حسین فروغی
شماره صفحات3999
شماره مجلد42
ضریب تاثیر (IF)1.833
نوع مقالهFull Paper
تاریخ انتشار2016-04-11
رتبه نشریهعلمی - پژوهشی
نوع نشریهالکترونیکی
کشور محل چاپایران
نمایه نشریهISI ,SCOPUS

چکیده مقاله

In this research, ZnS nanoparticles were prepared and applied as heterogeneous reusable catalyst for synthesis of 1,5-benzodiazepines under grinding conditions at 70 °C. The multi-component reactions of aldehydes, dimedone and o-phenylenediamine were carried out under grinding conditions to obtain some 3,3-dimethyl-2,3,4,5,10,11-hexahydro-11-[aryl]-1H-dibenzo[b,e][1,4] diazepine-1-one derivatives. The present approach provides several advantages, including high yields, short reaction times, little catalyst loading and purification of compounds by crystallization method. The catalyst was characterized by using FT-IR, XRD, PL, EDX, SEM and TEM techniques.

tags: 1,5-Benzodiazepines, ZnS nanoparticles, Dimedoneo-Phenylenediamine, Aromatic aldehyde, Grinding