Simultaneous Determination of Isoproterenol, Acetaminophen and Folic Acid Using a Novel Nanostructure-Based Electrochemical Sensor

نویسندگانمحمد مظلوم اردکانی,لاله حسین زاده,علیرضا خوشرو,حسین نعیمی,محسن مرادیان
شماره صفحات275
شماره مجلد26
ضریب تاثیر (IF)2.138
نوع مقالهFull Paper
تاریخ انتشار2014-02-11
رتبه نشریهعلمی - پژوهشی
نوع نشریهالکترونیکی
کشور محل چاپایران
نمایه نشریهISI ,SCOPUS ,PubMed

چکیده مقاله

In this study, a carbon paste electrode modified with (E)-2-((2-chlorophenylimino)methyl)benzene-1,4-diol (CD) and titanium dioxide nanoparticles (TiO2) was used to prepare a novel electrochemical sensor. The objective of this novel electrode modification was to seek new electrochemical performances for the detection of isoproterenol (IP) in the presence of acetaminophen (AC) and folic acid (FA). Initially, cyclic voltammetry (CV) was used to investigate the redox properties of this modified electrode at various scan rates. In the following, the mediated oxidation of IP at the modified electrode was described. The results showed an efficient catalytic activity of the electrode for the electrooxidation of IP, which leads to a reduction in its overpotential by more than 235 mV. The value of the electron transfer coefficient (α), catalytic rate constant (kh) and diffusion coefficient (D) were calculated for IP, using electrochemical approaches. Based on differential pulse voltammetry (DPV), the oxidation of IP exhibited a dynamic range between 0.5 and 1000 µM and a detection limit (3σ) of 0.47 µM. DPV was used for simultaneous determination of IP, AC and FA at the modified electrode. Finally, this method was used for the determination of IP in real samples, using standard addition method.

tags: Acetaminophen;Electrochemistry;Folic acid;Isoproterenol;Nanoparticles