A facile one-pot ultrasound assisted for an efficient synthesis of 1H-spiro[furo[3,4-b]pyridine-4,30-indoline]-3-carbonitriles

نویسندگانرامین قهرمان زاده,زهرا رشید,امیر حسن زرنانی,حسین نعیمی
شماره صفحات1451
شماره مجلد21
ضریب تاثیر (IF)4.321
نوع مقالهFull Paper
تاریخ انتشار2014-02-11
رتبه نشریهعلمی - پژوهشی
نوع نشریهالکترونیکی
کشور محل چاپایران
نمایه نشریهISI ,SCOPUS

چکیده مقاله

A convenient one-pot protocol was developed for the synthesis of 1H-spiro[furo[3,4-b]pyridine-4,30-indoline]- 3-carbonitrile derivatives. This reaction was carried out through a three component condensation reaction of isatins, malononitrile, and anilinolactones in the presence of a catalytic amount of Et3N as an inexpensive and available basic catalyst in THF under ultrasound irradiation. The products were obtained in high yields and short reaction times. The main advantage of this synthetic method is that the obtained products in ultrasonic irradiations are different from classical heating.

tags: Multi-component reaction; Ultrasound; Spirooxindole; Malononitrile; Isatin; Tetronic acid