Facile and mild synthesis of 1-substituted-1H-1,2,3,4-tetrazoles catalyzed by methanesulfonic acid under solvent-free conditions

نویسندگانحسین نعیمی,فاطمه کیانی,محسن مرادیان
نشریهIranian Journal of Catalysis
شماره صفحات243
شماره مجلد3
نوع مقالهFull Paper
تاریخ انتشار2013-12-11
رتبه نشریهعلمی - پژوهشی
نوع نشریهالکترونیکی
کشور محل چاپایران
نمایه نشریهISC ,SID

چکیده مقاله

Methanesulfonic acid (MSA) was found to be an efficient catalyst for the synthesis of 1-substituted-1H-1,2,3,4-tetrazoles. A series of 1-substituted tetrazole compounds were synthesized from the reaction of various primary amines, sodium azide and triethyl orthoformate in the presence of catalytic amounts of MSA at room temperature. In this protocol, some of the tetrazole derivatives were synthesized in good to excellent yields and convenient reaction times. This method has the advantages of simple methodology and easy work-up.

tags: 1H-tetrazole, methanesulfonic acid, solvent-free, primary amines