An Efficient One-Pot Multicomponent Synthesis of 4-Aza-Podophyllotoxin Derivatives in Ionic Liquid

نویسندگانحسین نعیمی,زهرا رشید,امیرحسن زرنانی,رامین قهرمان زاده
نشریهE-J CHEM
شماره صفحات1
شماره مجلد2013
نوع مقالهFull Paper
تاریخ انتشار2013-10-11
رتبه نشریهعلمی - پژوهشی
نوع نشریهالکترونیکی
کشور محل چاپایران
نمایه نشریهISI ,SCOPUS

چکیده مقاله

A simple, green, and efficient procedure for the synthesis of 4-aza-podophyllotoxin derivatives by using a one-pot three-component reaction of benzaldehydes, 1,3-cyclohexanediones, and anilinolactones in the presence of catalytic amount of alum in 1-butyl-3-methylimidazolium triflate as green media is described. This reaction proceeded under mild conditions with the use of an inexpensive and readily available catalyst, high to excellent yields, and simple workup procedure.

tags: One-Pot, Multicomponent, 4-Aza-Podophyllotoxin, Ionic Liquid