| نویسندگان | عبد الحمید بامنیری,محمدرضا قلی بیکیان,محمدحسین هوشدارتهرانی,بی بی فاطمه میرجلیلی |
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| همایش | اولین کنگره ملی پژوهش و نوآوری در زیست فناوری |
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| تاریخ برگزاری همایش | 2017-4-27 |
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| محل برگزاری همایش | اصفهان |
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| نوع ارائه | سخنرانی |
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| سطح همایش | ملی |
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چکیده مقاله
In this study, HCC was induced by diethylnitrosamine (DEN), as an initiator, and 2-
acetylaminofluorene (2-AAF), as a promoter. Rat liver hepatocytes and mitochondria for
evaluation of the selective cytotoxic effect of Carnosine dipeptide analogues was isolated
and cellular parameters related to apoptosis signaling were then determined. Our results
showed that high toxicity synthesized linear and cyclic Carnosine analogues with
concentration 10 μg/mL in MTT assay, a raise in mitochondrial reactive oxygen species
(ROS) level, after exposure of mitochondria only isolated from the Hepatocellular
carcinoma (HCC group). Based on the overall results, cyclic Carnosine analogues against
linear Carnosine analogues would be encouraging to develop new anticancer agents and
may be considered as a promising complementary therapeutic agents for the treatment of
HCC. The synthesized Carnosine analogues were characterized by using different
methods such as, LC-MS.
