Nano silica phosphoric acid as an efficient catalyst for one-pot synthesis of 2,4,5-trisubstituted imidazoles under solvent free condition

چکیده مقاله

Nano silica phosphoric acid has been found to be an extremely efficient catalyst for the preparation of 2,4,5- trisubstituted imidazoles via three-component reactions of benzil, aldehydes and ammonium acetate under solvent free conditions. This process is simple and environmental benign in good to excellent yields. Furthermore, the catalyst can be recovered conveniently and reused for at least three times with a gradual decline in activity.